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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10488 | BCR-ABL-IN-1 | Bcr-Abl | |
BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia. | |||
T11916 | Lyn-IN-1 | Bafetinib analog | Bcr-Abl , Src |
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn | |||
T21785 | AG957 | Bcr-Abl | |
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. | |||
T64338 | AKI603 | AKI 603,AKI-603 | Aurora Kinase |
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l... | |||
T37600 | Dasatinib N-oxide | Others | |
Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib.It is also a potential impurity in commercial preparations of dasatinib[1][2]. | |||
T3S1553 | Trans-Cinnamaldehyde | Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein | COX , Endogenous Metabolite |
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells... | |||
T82909 | BCR-ABL-IN-8 | Bcr-Abl | |
BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1]. | |||
T18694 | SNIPER(ABL)-050 | Others | |
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1]. | |||
T11977 | Mcl1-IN-9 | BCL | |
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM. | |||
T77974 | PROTAC BCR-ABL Degrader-1 | PROTACs | |
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and demonstrates antiproliferative effects on K562 cells, suggesting its... | |||
T61324 | BCR-ABL1-IN-1 | ||
BCR-ABL1-IN-1 is a highly potent and orally bioavailable inhibitor, displaying remarkable specificity towards ABL kinase. Notably, this compound holds significant promise for delineating the precise involvement of ABL ki... | |||
T77969 | SIAIS100 TFA | Bcr-Abl | |
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader, exhibiting a DC50 of 2.7 nM. It is utilized in the research of chronic myeloid leukemia (CML) [1]. | |||
T75012 | SIAIS100 | ||
SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy. It is primarily utilized in the investigation of chronic myeloid leukemia (CML) [1]. | |||
T71313 | BVB-808 | ||
BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative... | |||
T73973 | Imatinib Impurity E | ||
Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhib... | |||
T36578 | Boc-Lys(Ac)-AMC | ||
Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G p... |